Sirtuin Axis
Sirtuins (SIRT1–SIRT7) are NAD+-dependent class-III lysine deacylases that regulate metabolism, stress response, DNA repair, and circadian rhythm. They consume NAD+ stoichiometrically · sirtuin activity scales with cellular NAD+ availability. NAD+ precursor supplementation (NR, NMN) is the dominant translational approach for sirtuin activation.
