PEPTIDES FOR WEIGHT LOSS

the triple-receptor incretin agonist leads published trial data. The Phase 2 NEJM trial (Jastreboff 2023, PMID 37366315) reported -24.2% LS mean body weight at the 12 mg dose arm at 48 weeks. the GLP-1 / GIP dual agonist at 15 mg in SURMOUNT-1 reached -22.5% at 72 weeks. the long-acting GLP-1 agonist 2.4 mg in STEP-1 reached -14.9% at 68 weeks. the triple-receptor incretin agonist is investigational. the GLP-1 / GIP dual agonist is FDA-approved as separate FDA-approved class members. the long-acting GLP-1 agonist is FDA-approved as an FDA-approved class member.

Some incretin agonists are FDA approved as prescription drugs. the GLP-1 / GIP dual agonist (separate FDA-approved class members), the long-acting GLP-1 agonist (separate FDA-approved class members), and the daily GLP-1 agonist (the FDA-approved class member) are FDA approved. the triple-receptor incretin agonist, the GLP-1 / glucagon dual agonist, the oral GLP-1 receptor mimetic, the GLP-1 / glucagon dual agonist (β) and the amylin receptor agonist are investigational. Research-grade material sold as a reference compound is for in-vitro laboratory use only, distinct from any branded prescription product.

the triple-receptor incretin agonist is a triple GLP-1 plus GIP plus glucagon agonist. the GLP-1 / GIP dual agonist is a dual GLP-1 plus GIP agonist. The added glucagon arm in the triple-receptor incretin agonist drives a thermogenic / energy-expenditure component on top of the appetite and insulin effects. Phase 2 the triple-receptor incretin agonist produced -24.2% body-weight reduction at 48 weeks vs the GLP-1 / GIP dual agonist -22.5% at 72 weeks. See the full /vs/the triple-receptor incretin agonist-vs-the GLP-1 / GIP dual agonist comparison.

All compounds on this page are supplied as research-grade chemical reference material for in-vitro laboratory studies. Each compound page documents the published trial dosing schedule, half-life, mechanism, and per-receptor pharmacology. GigaResearch does not recommend any human dose. For purchase of research-grade material see gigacompounds.com.