▶ HUMANIN · SUBTOPIC · SAFETY PROFILE
HUMANIN Safety Profile
For Laboratory Research Use Only. This page summarises observed adverse events and regulatory status reported in the peer- reviewed literature. It is not medical advice and does not recommend any human use of HUMANIN.
OBSERVED ADVERSE EVENTS IN LITERATURE
The following adverse events have been observed in trials or animal studies of HUMANIN. Severity, frequency, and attribution depend on the source publication.
- Limited human safety data · most research is preclinical
DRUG INTERACTIONS
The following interactions are reported in or theorised from the published mechanism for HUMANIN.
- Largely unstudied in humans
CONTRAINDICATIONS REPORTED IN LITERATURE
Contraindications recorded for HUMANIN in the published record:
- None established · research compound only
FDA REGULATORY STATUS
Not FDA-approved. Research-use only.
WADA REGULATORY STATUS
Not currently listed on the WADA Prohibited List.
SAFETY Q+A FROM LITERATURE
▶ Is humanin FDA-approved?
No. Humanin is research-use only. No FDA-approved indication.
CITED LITERATURE
The safety statements above are drawn from the following peer-reviewed sources. Refer to the originals for adverse- event tables, attribution, and full context.
- Hashimoto Y, Niikura T, Tajima H, et al.. A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta. Proc Natl Acad Sci U S A 2001. PMID 11371641. link
- Muzumdar RH, Huffman DM, Atzmon G, et al.. Humanin: a novel central regulator of peripheral insulin action. PLoS One 2009. PMID 19470690. link
- Lee C, Zeng J, Drew BG, et al.. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab 2015. PMID 25738459. link
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▶ LAST UPDATED · 2026-05-19