NO. 025 · GROWTH
KISSPEPTIN-10
HPG Axis Trigger
ALIASES
Kisspeptin-10, KP-10, Metastin-10, KISS1(112-121)
CLASS
Synthetic kisspeptin C-terminal active fragment · GnRH-axis upstream activator
FORMULA
C₆₃H₈₃N₁₇O₁₄
SEQUENCE
Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
HALF-LIFE
Very short (minutes) plasma
ROUTES
Subcutaneous (research) · Intravenous (clinical research)
MECHANISM OF ACTION
Ten-amino-acid C-terminal fragment of kisspeptin (encoded by KISS1). Direct GPR54 (KISS1R) agonist driving endogenous GnRH neuron firing and downstream LH/FSH release. Imperial College London reproductive-medicine research; investigational anti-anhedonia signal.
EVIDENCE GRADES
Dhillo 2005 JCEM · single SC kisspeptin-10 doses produce LH/FSH pulses.
Kisspeptin-54 (not 10) Phase 2 trigger for oocyte maturation in IVF (Abbara 2014/2017).
Restoration of LH pulsatility in hypothalamic amenorrhea reported in pilot trials.
SAFETY
Side effects
- Generally well-tolerated at research doses
- Mild injection-site discomfort
Drug interactions
- Other GnRH-axis modulators (GnRH agonists/antagonists, hCG)
Contraindications
- Active sex-hormone-sensitive malignancy
REGULATORY STATUS
FDA · Not FDA-approved. Research-use only in the United States.
WADA · Not specifically named on the 2024 Prohibited List. GnRH-axis-active compounds (e.g., hCG) are prohibited for male athletes under S2; kisspeptin may fall under regulator discretion.
STORAGE
Lyophilized · -20 °C 24 months
Reconstituted · 2-8 °C, 14-21 days
PEER-REVIEWED EVIDENCE
- Dhillo WS, Chaudhri OB, Patterson M, et al.. Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males. J Clin Endocrinol Metab 2005. PMID 15883247. link →
- de Roux N, et al.. Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proc Natl Acad Sci U S A 2003. PMID 12944565. link →
FAQ · 7 QUESTIONS
▶ What is kisspeptin-10?
Kisspeptin-10 (KP-10) is the 10-amino-acid C-terminal active fragment of the human KISS1 gene product. It is the principal upstream activator of the hypothalamic GnRH neuron firing pattern and downstream pituitary LH/FSH release.
▶ What does kisspeptin do?
Kisspeptin-10 binds the KISS1R / GPR54 receptor on hypothalamic GnRH neurons, triggering Gαq signaling, neuronal depolarization, and downstream GnRH secretion. The result is a pulse of LH and FSH from the anterior pituitary, increasing gonadal steroid production.
▶ Is kisspeptin FDA-approved?
No. Kisspeptin-10 is research-use only. No FDA-approved indication.
▶ How does kisspeptin differ from GnRH?
Kisspeptin acts upstream of GnRH · it triggers the GnRH neuron to fire. GnRH itself is the direct hypothalamic neuropeptide that acts on the anterior pituitary gonadotrophs.
▶ What research uses kisspeptin?
Reproductive endocrinology · IVF oocyte-maturation triggers (kisspeptin-54 specifically), hypothalamic amenorrhea reactivation, hypogonadotropic hypogonadism mechanistic studies, and sexual-function research.
▶ What's the difference between kisspeptin-10 and kisspeptin-54?
Kisspeptin-54 is the longer (54-residue) endogenous peptide; kisspeptin-10 is the shorter active fragment that is sufficient for receptor binding and biological activity. Both reduce to the same core C-terminal motif in vivo.
▶ Is kisspeptin-10 banned in sports?
Not specifically listed on the WADA Prohibited List as of 2026. Other GnRH-axis-active compounds (hCG, GnRH analogs) are prohibited for male athletes under S2.
SIGNATURE MOVES
Drives endogenous LH + FSH release.
Imperial College reproductive trials. Anti-anhedonia signal.
SOURCED FROM GIGACOMPOUNDS
Reference compounds documented on this page are available as research-grade material at GigaCompounds · ≥99% purity · per-batch Certificate of Analysis. For laboratory research use only. No human dose is recommended by this wiki.
▶ LAST UPDATED · 2026-05-19