HEAD-TO-HEAD

ADAMAX VS BPC-157

Adamax and BPC-157 are two tissue-protective research peptides with different origins. Adamax is an EPO-derived peptide analog related to ARA-290 / cibinetide, engineered to activate the innate-repair-receptor (IRR · EPOR + βcR heterocomplex) without stimulating red-blood-cell production. BPC-157 is a 15-aa gastric-origin pentadecapeptide acting through VEGF, NO, and growth-hormone-receptor upregulation. Different receptor pathways, both framed as tissue-protective.

A · No. 016

ADAMAX

ARA-290 peptide analog · tissue-protective research compound

B · No. 003

BPC-157

Pentadecapeptide Cytoprotection

SIDE BY SIDE

FIELD

A · ADAMAX

B · BPC-157

Class

EPO-derived non-erythropoietic peptide analog

Synthetic 15-aa peptide (gastric-origin fragment)

Sequence

ARA-290-class · short EPO-derived peptide

Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val

Mechanism

Innate-repair-receptor (EPOR + βcR) activation · no erythropoietic activity

VEGF / NO / GHR upregulation · cytoprotection paradigm

Primary research focus

Neuroprotection · anti-inflammatory · diabetic neuropathy (ARA-290 small-cohort data)

GI mucosal protection · tendon-ligament healing

Half-life

Short (minutes) plasma

~4 hours (rat, intraperitoneal)

Gastric stability

Not characterized as orally stable

Stable >24 hr in human gastric juice (unusual)

FDA status

Not FDA-approved · research chemical

FDA Cat 2 503A bulks list (Sept 2023) · research-use only

WADA status

EPO-class status under S2 may apply

Prohibited at all times (S0)

WHICH IS BETTER · BY GOAL

▶ Neuroprotection / neuropathy researchA · ADAMAX

ARA-290 (the closest characterized analog) has small-cohort clinical data in sarcoidosis-related small-fiber neuropathy and rodent diabetic-neuropathy models. BPC-157 is not specifically studied in peripheral neuropathy.

▶ GI mucosal protection researchB · BPC-157

BPC-157 has the Sikiric multi-paper rat-model evidence base for gastric and intestinal cytoprotection. Adamax is not specifically studied in GI research.

▶ Tendon / ligament researchB · BPC-157

Animal-model evidence for BPC-157 in Achilles detachment and transected quadriceps. Adamax is not specifically studied in tendon/ligament biology.

▶ Non-erythropoietic EPO-pathway researchA · ADAMAX

Adamax is the engineered probe for IRR activation without RBC stimulation. BPC-157 does not engage the EPO/IRR axis.

STACKING NOTE

Adamax and BPC-157 act on different receptor systems (IRR vs VEGF/NO/GHR) and could in principle complement each other in tissue-protective research, but no published study examines the combination. Buyers researching the tissue-protective category typically use each as a standalone reference compound.

SOURCED FROM GIGACOMPOUNDS

Both compounds are available as research-grade material at GigaCompounds · ≥99% purity · per-batch CoA. For laboratory research use only.

SOURCE AT GIGACOMPOUNDS ▶