HEAD-TO-HEAD

IGF-1 LR3 VS IPA / CJC-1295

Both target the GH/IGF-1 axis but at different layers. IGF-1 LR3 is the modified IGF-1 analog that directly engages the IGF-1 receptor, bypassing the GH axis entirely. Ipamorelin + CJC-1295 are upstream secretagogues · they stimulate the pituitary to release endogenous GH, which drives hepatic IGF-1 production. Direct downstream vs upstream pulsatile.

A · No. 017

IGF-1 LR3

Long R3 IGF-1 · extended half-life anabolic research compound

B · No. 009

IPA / CJC-1295

GH-Secretagogue Pair · Pulsatile

SIDE BY SIDE

FIELD

A · IGF-1 LR3

B · IPA / CJC-1295

Mechanism layer

Downstream · direct IGF-1R agonism

Upstream · GHRH-R + ghrelin-R agonism → pituitary GH pulse

Half-life

~6 hours (LR3 modification)

Ipa ~2 hr · CJC-1295 No DAC ~30 min

Receptor engaged

IGF-1 receptor (tyrosine kinase)

GHRH-R + GHS-R1a (GPCRs)

Hypoglycemia risk

Yes (binds insulin receptor at higher doses)

Low

Pulse vs sustained

Sustained 6-hour exposure

Pulsatile (mimics natural rhythm)

WADA status

Prohibited at all times (S2)

WHICH IS BETTER · BY GOAL

▶ Maximum IGF-1 receptor activationA · IGF-1 LR3

Direct receptor engagement bypasses any rate-limiting steps in the GH-axis. Higher peak receptor occupancy per dose.

▶ Physiological pulsatile rhythmB · IPA / CJC-1295

Ipa + CJC-1295 No DAC produces a GH pulse that approximates the natural diurnal pattern, which downstream IGF-1 inherits.

▶ Safety profile (community-reported)B · IPA / CJC-1295

Selective ghrelin agonism (ipamorelin) avoids cortisol and prolactin elevation seen with older GHS. GHRH agonism (CJC-1295) acts upstream so endogenous feedback regulates total exposure.

STACKING NOTE

Not commonly stacked together in community protocols · they target the same axis at different layers. IGF-1 LR3 is typically used as a standalone direct-IGF-1R compound; Ipa/CJC-1295 as a pulsatile-GH-axis pair.

SOURCED FROM GIGACOMPOUNDS

Both compounds are available as research-grade material at GigaCompounds · ≥99% purity · per-batch CoA. For laboratory research use only.

SOURCE AT GIGACOMPOUNDS ▶