HEAD-TO-HEAD

TESAMORELIN VS IPA / CJC-1295

Both are GHRH-axis research compounds, but tesamorelin is FDA-approved (Egrifta®) while CJC-1295 No DAC is research-use only. Tesamorelin is a stabilized GHRH(1-44) · the full natural 44-aa hormone sequence. CJC-1295 No DAC is a GHRH(1-29) analog · the shorter active fragment with stabilizing substitutions. The IPA/CJC-1295 pair adds ghrelin-receptor agonism via ipamorelin.

A · No. 008

TESAMORELIN

GHRH Analog · Egrifta®

B · No. 009

IPA / CJC-1295

GH-Secretagogue Pair · Pulsatile

SIDE BY SIDE

FIELD

A · TESAMORELIN

B · IPA / CJC-1295

Parent sequence

GHRH(1-44) · full natural hormone

GHRH(1-29) · active fragment

Length

44 amino acids

29 amino acids (CJC-1295) + 5 amino acids (ipamorelin)

Half-life

~26 min

CJC-1295 No DAC ~30 min · ipamorelin ~2 hr

Receptor engaged

GHRH-R only

GHRH-R (CJC) + GHS-R1a (ipamorelin)

FDA status

Approved (Egrifta®, Egrifta SV®)

Not FDA-approved · research-use only

Approved indication

Reduction of excess abdominal fat in HIV lipodystrophy

None

WADA status

Prohibited at all times (S2)

WHICH IS BETTER · BY GOAL

▶ FDA-validated visceral-fat researchA · TESAMORELIN

Tesamorelin has the only FDA-approved label for visceral-adipose reduction. Pooled Phase 3 -15.4% VAT at 26 weeks (Falutz 2010 PMID 20554713).

▶ Pulsatile dual-pathway GH activationB · IPA / CJC-1295

IPA/CJC-1295 combines GHRH-receptor + ghrelin-receptor stimulation, producing larger GH pulses via dual-pathway activation. Tesamorelin engages GHRH-R only.

▶ Cost-per-pulse research budgetB · IPA / CJC-1295

Tesamorelin (Egrifta) is expensive at the branded human-prescription level. Research-grade CJC-1295 + ipamorelin is significantly cheaper for laboratory characterization.

STACKING NOTE

Tesamorelin + IPA/CJC-1295 = the GH-Axis Trifecta stack · three complementary upstream regulators of the GH pulse. Combining multiple GH-axis agonists is not supported by published research; the stack is a reference framing rather than a clinical protocol.

SOURCED FROM GIGACOMPOUNDS

Both compounds are available as research-grade material at GigaCompounds · ≥99% purity · per-batch CoA. For laboratory research use only.

SOURCE AT GIGACOMPOUNDS ▶